Comparative effects of surfactants (SLS and LAS) on the dermal absorption of a series of compounds in isolated perfused skin.
Toxicologist 2008 Mar; 102(1):320
Surfactants are a common constituent of many complex chemical mixtures encountered in occupational and environmental waste exposure scenarios. This study focused on assessing the effect of the surfactants sodium lauryl sulfate (SLS) or linear alkylbenzene sulfonate (LAS) on the dermal penetration and absorption on aqueous solutions of six chemicals (fenthion, parathion, para-nitrophenol, phenol, propazine and triazine) dosed topically on the isolated perfused porcine skin flap (IPPSF) model. SLS and LAS were selected because of their widespread applicability to practical dermal exposure scenarios, and their molecular similarity differing only in the absence or presence, respectively, of an aromatic ring in their polar head region. IPPSF absorption was assessed into perfusate, stratum corneum, and skin using radioassay of 14C labeled compounds, with absorption parameters for individually- dosed compounds in SLS and LAS compared to aqueous controls without surfactant. Across all penetrants, absorptive flux and skin penetration was greater with SLS compared to LAS. The relationship of absorption from water varied, with surfactant treatments less than water for para-nitrophenol, parathion, fenthion and propazine, while absorption from water was intermediate between SLS and LAS for phenol and triazine. Surfactants also had variable effects of maximum flux. This work begins to establish a relationship between the physical chemical properties of penetrants and properties of the surfactant, an important phenomenon to understand when predicting chemical absorption from common mixtures.
Surfactants; Skin-absorption; Skin-exposure; Pesticides; Insecticides; Phenols
55-38-9; 56-38-2; 100-02-7; 108-95-2; 139-40-2
Work Environment and Workforce: Mixed Exposures
The Toxicologist. Society of Toxicology 47th Annual Meeting and ToxExpo, March 16-20, 2008, Seattle, Washington
North Carolina State University, Raleigh, North Carolina