Use of a multi-fiber approach to quantify chemical mixture interactions modulating dermal absorption.
Imran-M; Baynes-RE; Xia-X; Riviere-JE
Toxicologist 2008 Mar; 102(1):319
Chemical mixtures can potentially increase or decrease systemic bioavailability of toxicants in a mixture. Dermal permeability can be modulated by changes in physicochemical interactions between mixture, skin and the solute of interest. These physicochemical interactions can be described as changes in system coefficients associated with molecular descriptors described by Abraham's linear solvation energy relationship (LSER). This study evaluated the effects of chemical mixtures containing either a solvent (ethanol) or a surfactant (sodium lauryl sulfate, SLS) on solute permeability and partitioning by quantifying changes in system coefficients in skin and a three membrane coated fiber (MCF) system, respectively. Regression analysis demonstrated that changes in system coefficients in skin were strongly correlated (R2=0.89-0.98) to changes in system coefficients in the 3-membrane MCF array with mixtures containing either 1% SLS or 50% ethanol. The PDMS fiber appeared to play a significant role (R2=0.84-0.85) in the MCF array in predicting changes in solute permeability, while the WAX fiber appeared to contribute less (R2=0.59-0.77) to the array than the other 2 fibers. Based on changes in system coefficients that are part of a linear solvation energy relationship (LSER), these experiments were able to link physicochemical interactions in the MCF with those interactions in skin when either system is exposed to 1% SLS or 50% ethanol. These experiments further demonstrated the utility of a MCF array to adequately predict changes in dermal permeability when skin is exposed to mixtures containing either a surfactant or solvent, and provide insight into the nature of the physiochemical interactions which modulate dermal absorptions.
Contact-allergies; Contact-dermatitis; Cell-damage; Chemical-hypersensitivity; Chemical-properties; Allergic-dermatitis; Cytotoxic-effects; Cytotoxins; Mathematical-models; Statistical-analysis; Risk-analysis; Quantitative-analysis; Physiological-chemistry; Physical-reactions; Physical-chemistry; Dermatitis; Skin-absorption; Diffusion-analysis; Analytical-models; Analytical-chemistry
Work Environment and Workforce: Mixed Exposures; Disease and Injury: Allergic and Irritant Dermatitis
The Toxicologist. Society of Toxicology 47th Annual Meeting and ToxExpo, March 16-20, 2008, Seattle, Washington
North Carolina State University, Raleigh, North Carolina