In vivo cyclical joint loading decreases unmineralized cartilage thickness in the rabbit metacarpophalangeal.
Opel-C; Rempel-D; King-KB
Trans Annu Meet Orthop Res Soc 2005 Mar; 51:1638
Understanding the mechanobiology of joint loading is essential for progress in treating osteoarthritis as well as other degenerative joint diseases and to help engineer cartilage tissue replacements. This study examines articular joint tissue changes resulting from in vivo cyclical loading in a rabbit model. This new animal model has the potential to advance our understanding of adult endochondral ossification and degenerative joint disease.
In-vivo-studies; Injuries; Laboratory-animals; Animal-studies; Muscles; Repetitive-work; Cumulative-trauma-disorders; Cumulative-trauma; Musculoskeletal-system; Musculoskeletal-system-disorders; Biomechanics; Laboratory-animals; Models; Bone-disorders
Department of Medicine, University of California, San Francisco, CA
Abstract; Conference/Symposia Proceedings
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Transactions of the Annual Meeting of the Orthopaedic Research Society
University of California - San Francisco