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The effect of loading rate on VEGF, VEGFR-1 and CTGF production in an in vivo cyclically loaded tendon.

Nakama-LH; Wu-CC; King-KB; Rempel-DM
Trans Annu Meet Orthop Res Soc 2006 Mar; 52:1095
Soft tissue injuries are common in athletes and workers whose job functions require repetitive, high force hand activities. The exact mechanisms leading to tendinopathy are unknown but both biomechanical and biochemical factors play an important role. VEGF has been found in human biopsies of degenerated tendons and in cyclically strained fibroblast cell cultures, indicating that it may play a role in overuse injuries leading to tendon degeneration. One of the main receptors for VEGF, VEGFR-1, which has the highest affinity for VEGF, has been shown to be up-regulated during angiogenesis and hypoxic conditions. Another growth factor in tendons, connective Tissue Growth Factor (CTGF), is a potent inducer of extracellular matrix synthesis and is up-regulated by tensile stresses. Recently, these proteins were shown to increase in cyclically loaded tendons exposed to repetition rates of 60 reps/min. The purpose of this study was to evaluate changes in VEGF, VEGFR-1 and CTGF cell density in the FDP tendon at the epicondyle following in vivo cyclical finger loading at a lower repetition rate (10 reps/min), but the same force and duty cycle, using a rabbit model.
In-vivo-studies; Models; Injuries; Laboratory-animals; Animals; Animal-studies; Muscles; Repetitive-work; Cumulative-trauma-disorders; Cumulative-trauma; Musculoskeletal-system; Musculoskeletal-system-disorders; Biomechanical-modeling; Biomechanics; Hand-injuries
Publication Date
Document Type
Conference/Symposia Proceedings; Abstract
Email Address
Funding Type
Fiscal Year
Identifying No.
Priority Area
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Source Name
Transactions of the Annual Meeting of the Orthopaedic Research Society
Performing Organization
University of California - San Francisco
Page last reviewed: September 2, 2020
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