Effect of repetition rate on blood vessel formation in the paratenon of a repetitively loaded tendon in vivo.
Nakama-LH; Amano-K; King-KB; Rempel-DM
Trans Annu Meet Orthop Res Soc 2006 Mar; 52:1096
Soft tissue injuries are common in athletes and workers whose job functions require the use of repetitive high force hand activities. The exact mechanisms leading up to tendinopathy is unknown but both biomechanical and biochemical factors play a significant role. Previously Vascular Endothelial Growth Factor, VEGF, had been found in human biopsies of degenerated tendons and in cyclically strained fibroblast cell cultures (1). Recently, this protein was shown to increase with loading (2) using a repetition rate of 60 reps/min, where the highest levels were found in the outer regions of the tendon, next to the paratenon. VEGF is responsible for stimulating the proliferation of microvascular endothelial cells and inducing angiogenesis. The purpose of this study was to evaluate changes in blood vessel number in the paratenon of the FDP tendon at the epicondyle following in vivo cyclical finger loading at different repetition rates (10 versus 60 reps/min), but the same force and duty cycle using a rabbit model.
In-vivo-studies; Models; Injuries; Laboratory-animals; Animals; Animal-studies; Muscles; Repetitive-work; Cumulative-trauma-disorders; Cumulative-trauma; Musculoskeletal-system; Musculoskeletal-system-disorders
DM Rempel, University of California, San Francisco, CA
Abstract; Conference/Symposia Proceedings
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Transactions of the Annual Meeting of the Orthopaedic Research Society
University of California - San Francisco