NIOSHTIC-2 Publications Search

Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential - a workshop report and consensus statement.

Ayres JG; Borm P; Cassee F; Castranova V; Donaldson K; Ghio A; Harrison RM; Hider R; Kelly F; Kooter I; Marano F; Maynard RL; Mudway I; Nel A; Sioutas C; Smith S; Baeza-Squiban A; Cho A; Duggan S; Froines J

Inhal Toxicol 2008 Jan; 20(1):75-99

https://doi.org/10.1080/08958370701665517

20033191

Background: There is a strong need for laboratory in vitro test systems for the toxicity of airborne particulate matter and nanoparticles. The measurement of oxidative stress potential offers a promising way forward. Objectives: a workshop was convened involving leading workers from the field in order to review the available test methods and to generate a Consensus Statement. Discussions: workshop participants summarised their own research activities as well as discussion of the relative merits of different test methods. Conclusions: in vitro test methods have an important role to play in the screening of toxicity in airborne particulate matter and nanoparti- cles. In vitro cell challenges were preferable to in vitro acellular systems but both have a potential major role to play and offer large cost advantages relative to human or animal inhalation studies and animal in vivo installation experiments. There remains a need to compare tests one with another on standardised samples and also to establish a correlation with the results of population-based epidemiology.

Sampling; Sampling-methods; Analytical-methods; Air-contamination; Air-quality-measurement; Air-samples; Air-sampling-techniques; Airborne-dusts; Airborne-particles; Particle-aerodynamics; Particulate-dust; Particulate-sampling-methods; Particulates; Dust-analysis; Dust-exposure; Toxic-effects; Cell-biology; Cell-differentiation; Cellular-reactions; Oxidative-metabolism; Nanotechnology

Roy M. Harrison, Division of Environmental Health & Risk Management, School of Geography, Earth & Environmental Sciences, Edgbaston, Birmingham B15 2TT, UK

INHTE5

20080101

Journal Article

r.m.harrison@bham.ac.uk

2008

1

0895-8378

HELD

Manufacturing

Inhalation Toxicology

WV; NC; CA