NIOSHTIC-2 Publications Search

Confidence interval construction for relative toxicity endpoints such as LD50 or LD90 ratios.

Authors
Wheeler-M; Fadel-W; Robertson-J; Bailer-AJ
Source
J Econ Entomol 2007 Dec; 100(6):1945-1949
NIOSHTIC No.
20033186
Abstract
A common measure of the relative toxicity is the ratio of median lethal doses for responses estimated in two bioassays. Robertson and Preisler previously proposed a method for constructing a confidence interval for the ratio. The applicability of this technique in common experimental situations, especially those involving small samples, may be questionable because the sampling distribution of this ratio estimator may be highly skewed. To examine this possibility, we did a computer simulation experiment to evaluate the coverage properties of the Robertson and Preisler method. The simulation showed that the method provided confidence intervals that performed at the nominal confidence level for the range of responses often observed in pesticide bioassays. Results of this study provide empirical support for the continued use this technique.
Keywords
Toxic-dose; Biological-agents; Biological-factors; Statistical-analysis; Analytical-models; Pesticides; Mathematical-models; Ecological-systems; Risk-analysis
Contact
M Wheeler, NIOSH, Risk Evaluation Branch, 4676 Columbia Parkway, Cincinnati, OH 45226
CODEN
JEENAI
Publication Date
20071201
Document Type
Journal Article
Email Address
mwheeler@cdc.gov
Fiscal Year
2008
Issue of Publication
6
ISSN
0022-0493
NIOSH Division
EID
Source Name
Journal of Economic Entomology
State
OH; CA
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division