Toxicity of single walled carbon nanotubes in vivo: relevance to occupational exposures.
European NanOSH Conference - Nanotechnologies: A Critical Area in Occupational Safety and Health, 3-5 December 2007, Helsinki, Finland. Helsinki, Finland: Finnish Institute of Occupational Health, 2007 Dec; :31
Nanotechnology is a fast growing field with emerging development of modern materials for electronics and information technology industries, cosmetics, health and medicine and in a variety of manufactured goods. Single-Walled Carbon Nanotubes (SWCNT) are new materials of emerging technological importance and have unique physico-chemical, electronic and mechanical properties. Therefore, they may exhibit unusual interactions with cells and tissues, thus necessitating studies of their toxicity and health effects. We have demonstrated that SWCNT in doses relevant to potential occupational settings may exert their toxic effects in vivo in the lung of exposed animals. SWCNT exposures of C57BU6 mice via inhalation and pharyngeal aspiration revealed that they are both elicited an unusual and robust inflammatory and fibrogenic response associated with the progression of oxidative stress and altered pulmonary function. Because realistic exposures to SWCNT are likely to occur in conjunction with other pathogenic impacts, e.g., microbial infections, our findings that bacterial clearance from the lungs of SWCNT exposed mice was compromised is of great importance. This talk will address important issues of respiratory toxicity of SWCNT causing substantial pulmonary injury; including fibrosis providing clues toward underlying mechanisms of toxicity with respect to current regulations insufficiently providing protection in occupational settings.
Toxicopathology; Toxic-effects; Respiratory-system-disorders; Respiratory-infections; Fibrosis; Fibrogenicity; Fibrogenesis; Pulmonary-system-disorders; Nanotechnology
Abstract; Conference/Symposia Proceedings
European NanOSH Conference - Nanotechnologies: A Critical Area in Occupational Safety and Health, 3-5 December 2007, Helsinki, Finland
University of Pittsburgh at Pittsburgh