NIOSHTIC-2 Publications Search

Molecular and cellular biomarker responses to pesticide exposure in juvenile chinook salmon (Oncorhynchus tshawytscha).

Eder KJ; Leutenegger CM; Wilson BW; Werne I

Mar Environ Res 2004 Aug-Dec; 58(2-5):809-813

https://doi.org/10.1016/j.marenvres.2004.03.098

20033135

We determined the effects of two pesticides, chlorpyrifos and esfenvalerate in juvenile Chinook salmon. Four to five month old salmon were exposed to a range of pesticide concentrations, and tissue samples of surviving fish were analyzed for stress protein expression, cytokine transcription, and acetylcholinesterase (AChE) activity. At the highest concentrations, both pesticides led to complete mortality, whereas medium and low concentrations resulted in high survival rates. Significant differences in stress protein expression, cytokine transcription and AChE activity were found between control and surviving chlorpyrifos-exposed fish. Elevated stress protein expression was the only detectable response to esfenvalerate.

Pesticides; Chemical-analysis; Sea-water; Cytotoxic-effects; Cytotoxicity; Cytotoxins; Proteins; Protein-biochemistry

MERSDW

2921-88-2; 66230-04-4

20040801

Journal Article

kjeder@ucdavis.edu

Agriculture; Cooperative Agreement

2004

Cooperative-Agreement-Number-U50-OH-007550

2-5

0141-1136

Marine Environmental Research

CA

University of California - Davis