Nuclear factor-kB, an unappreciated tumor suppressor.
Cancer Res 2007 Dec; 67(23):11093-11098
The notion that nuclear factor-B (NF-B) is a tumor-promoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-B in carcinogenesis and tumorigenesis. Although the tumor suppressor-like effect of NF-B remains to be rigorously established by further studies using cellular and animal models, these latest findings warrant caution with respect to blockage of NF-B activation as a broad strategy in treating cancers.
Nuclear-medicine; Cancer; Cell-morphology; Cell-biology; Cancer; Animal-studies
Fei Chen, The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505