DLC-1: a Rho GTPase-activating protein and tumour suppressor.
Durkin-ME; Yuan-BZ; Zhou-X; Zimonjic-DB; Lowy-DR; Thorgeirsson-SS; Popescu-NC
J Cell Mol Med 2007 Sep-Oct; 11(5):1185-1207
The deleted in liver cancer 1 (DLC-1) gene encodes a GTPase activating protein that acts as a negative regulator of the Rho family of small GTPases. Rho proteins transduce signals that influence cell morphology and physiology, and their aberrant up-regulation is a key factor in the neoplastic process, including metastasis. Since its discovery, compelling evidence has accumulated that demonstrates a role for DLC-1 as a bona fide tumour suppressor gene in different types of human cancer. Loss of DLC-1 expression mediated by genetic and epigenetic mechanisms has been associated with the development of many human cancers, and restoration of DLC-1 expression inhibited the growth of tumour cells in vivo and in vitro. Two closely related genes, DLC-2 and DLC-3, may also be tumour suppressors. This review presents the current status of progress in understanding the biological functions of DLC-1 and its relatives and their roles in neoplasia.
Proteins; Cell-growth; Tumorigenesis; Tumors; Tumorigens; Liver-cancer; Teratogenesis; Teratology; Biological-function; Biological-systems; Biological-effects; Biological-factors; Prostate-cancer
Nicholas C. Popescu, Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Building 37, Room 4128, 37 Convent Drive, MSC 4262, Bethesda, MD 20892-4262
Journal of Cellular and Molecular Medicine