The influence of co-pollutants on the toxicity of airborne particulate matter.
Toxicologist 2000 Mar; 54(1):244
Recent epidemiological reports have shown an association between ambient air particulate matter (PM) concentrations and human mortality and morbidity, such as increased hospitalizations. PM coexists in the ambient air with many other pollutants, and therefore complicates the assessment of the contribution of PM to the affected health endpoints. In the National Research Council's Report in 1998 that concerned Airborne PM Research Priorities, one of the research aspects emphasized was performance of controlled toxicological studies and epidemiological studies related to examining effects of co-pollutants on possible PM-induced health endpoints. In this session, evidence of the support for co-pollutant influences on PM-associated health effects will be examined from epidemiological studies. Evidence of co-pollutants affecting PM-induced responses will be will drawn from findings of controlled in vivo and in vitro exposure studies that examine cardiopulmonary effects of PM. These controlled co-pollutant studies can potentially suggest which pollutants are likely to influence PM-induced lung and extrapulmonary toxicity, and potential mechanisms for these interactions. Additionally, the characteristics and components of PM likely to be influenced by other ambient pollutants can be identified in these studies. Oxidants including ozone, inorganic components such as sulfates, organic constituents such as aromatic compounds, and biological substances (i.e., endotoxin) can all play an important role in modifying PM-induced effects by allowing co-pollutant interactions. Data presented from gaseous pollutant interaction with cigarette smoke, more typically an indoor pollutant, will compliment the understanding of outdoor PM toxicology.
Epidemiology; Air-quality; Air-quality-measurement; Air-samplers; Air-samples; Air-sickness; Humans; Pollutants; Toxicology; Cardiopulmonary-system-disorders; Indoor-air-pollution; Cigarette-smoking; Indoor-environmental-quality
Cooperative Agreement; Agriculture
The Toxicologist. Society of Toxicology 39th Annual Meeting, March 19-23, 2000, Philadelphia, Pennsylvania
University of California - Davis