A TGF-beta 1 polymorphism association with dementia and neuropathologies: the HAAS.
Peila-R; Yucesoy-B; White-LR; Johnson-V; Kashon-ML; Wu-K; Petrovitch-H; Luster-M; Launer-LJ
Neurobiol Aging 2007 Sep; 28(9):1367-1373
The transforming growth factor-beta 1 (TGF-beta 1) is involved in post-ischemic neuronal rescue and in P-amyloid turn-over. We hypothesized that the risk for dementia and related neuropathologies is modified by the TGF-beta 1 functional genetic variants. The association of the TGF-beta 1 + 29T ->) C polymorphism with dementia was examined in a sample of 261 cases and 491 controls from the Honolulu-Asia Aging Study, including 282 subjects with autopsy data. Dementia was assessed in 1991 and 1994 by a multi-step protocol and standardized diagnostic criteria. The analysis was adjusted for demographic and vascular factors. Compared to the TT genotype, the TC and the CC genotypes were associated with a reduced risk for vascular dementia (ORTC = 0.28, 95% confidence interval (CI): 0. 1-0.9; ORcc = 0.28, CI: 0. 1-0.9), microinfarcts (ORCC = 0.3 1, CI: 0. 13-0.7 1) and cerebral amyloid angiopathy (ORCC = 0.48, CI: 0.2-0.9). The CC genotype was associated with an increase risk of neocortical plaques (ORCC =4.34, CI: 1.6-11.8). These preliminary data suggest that the TGF genetic variability may be important in the risk of vascular related dementia.
Physiological-factors; Physiological-function; Physiological-measurements; Physiological-testing; Mental-health; Mental-disorders; Cerebrovascular-system-disorders; Brain-function
Rita Peila, Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Suite 3C-309, Bethesda, MD 20892-9205
Neurobiology of Aging