Exposure assessment considerations for nanoparticles in the workplace.
Hoover-MD; Stefaniak-AB; Day-GA; Geraci-CL
Nanotoxicology: Characterization, Dosing and Health Effects. Monteiro-Riviere NA, Tran CL, eds., New York: Informa Healthcare, 2007 Jul; :71-83
Many of the exposure assessment issues presented in this chapter indicate that most nanomaterial can be approached as a logical subset of traditional exposure assessment for chemical hazards in the workplace and environment. In a manner similar to concerns for special formulations of chemicals, the challenge for providing effective exposure assessment and protection of human and environmental health rests in recognition of when the unique size, surface, and compositional properties of nanomaterials may alter their ability to interact with biological systems. The question of what aspects of exposure should be assessed will continue to challenge heath protection professionals. A goal of the nanotechnology community should be to develop a nanomaterial specific compendium of information on materials at risk, damage ratios, airborne release fractions, respirable fractions, and biologically relevant particle characteristics for representative research, development, and manufacturing processes, handling and disposal situations, and potential accident scenarios. This will require a large number of site-specific studies. Not everything can be measured at all times, but intelligent approaches to exposure assessment can reduce risks from the outset and enable rapid learning of lessons with minimal risks to workers and members of the public.
Dose-response; Risk-analysis; Statistical-analysis; Exposure-assessment; Nanotechnology
Book or book chapter
Nanotoxicology: Characterization, Dosing and Health Effects