A nested case-control study of lung cancer risk and ionizing radiation exposure at the Portsmouth Naval Shipyard.
Yiin-JH; Silver-SR; Daniels-RD; Zaebst-DD; Seel-EA; Kubale-TL
Radiat Res 2007 Sep; 168(3):341-348
Results have been inconsistent between studies of lung cancer risk and ionizing radiation exposures among workers at the Portsmouth Naval Shipyard (PNS). The purpose of this nested case-control study was to evaluate the relationship between lung cancer risk and external ionizing radiation exposure while adjusting for potential confounders that included gender, radiation monitoring status, smoking habit surrogates (socioeconomic status and birth cohort), welding fumes and asbestos. By incidence density sampling, we age-matched 3,291 controls selected from a cohort of 37,853 civilian workers employed at PNS between 1952 and 1992 with 1,097 lung cancer deaths from among the same cohort. Analyses using conditional logistic regression were conducted in various model forms: log-linear (main), linear excess relative risk (ERR), and categorical. Lung cancer risk was positively associated with occupational dose (OR = 1.02 at 10 mSv; 95% CI 0.99 - 1.04) but flattened after the inclusion of work-related medical X-ray doses (OR = 1.00; 95% CI 0.98 - 1.03) in multivariate analyses. Similar risk estimates were observed in the linear ERR model at 10 mSv of cumulative exposure with a 15-year lag.
Lung-cancer; Respiratory-system-disorders; Pulmonary-system-disorders; Cancer; Cancer-rates; Case-studies; Ionizing-radiation; Radiation-exposure; Radiation-facilities; Demographic-characteristics; Statistical-analysis; Epidemiology; Risk-analysis
Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226