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Lack of association between HER2(V655) and breast cancer in a US population.

Authors
Keshava-C; McCanlies-EC; Wolff-MS; Weston-A
Source
Am J Hum Genet 2000 Oct; 67(4)(Suppl 2):105
NIOSHTIC No.
20032332
Abstract
A recent study in a population of Chinese women revealed an association between inheritance of a moderately common polymorphism (0.10-0.15) of HER2 (I655V) and excess risk of breast cancer (OR = 12.7, 95% CI = 1.6-99.5) (Xie et al., J. Natl. Cancer Inst., 92:412-417, 2000). Also, a stronger relationship was claimed in younger women (adjusted OR = 1.7, 95% CI = 1.1-2.6). We tested this hypothesis in a population of US women enrolled in a hospital based case control study in New York City (n = 137 cases and 291 controls, matched 1:2 on age and self-reported race/ethnicity). No evidence was found to support an association between inheritance of the 655-valine variant of HER2 and excess breast cancer risk. Our population consisted of African-Americans (n = 34 cases/58 controls), Caucasians (n = 77/162) and Latinas (26/71). Genotypic distributions for all groups were consistent with Hardy-Weinburg population laws (all p-valves fell within the range 0.16-0.91). Interestingly, HER2V655 allelic frequencies were found to vary with race (African-Americans 0.05, Caucasians 0.16, Latinas 0.15), differences between African-Americans and Caucasians and African-Americans and Latinas were significant (p-values = 0.002 and 0.001, respectively). No association was found between inheritance of HER2V655 and breast cancer, either in the group as a whole (carriers OR = 1.2, 0.8-1.9 or homozygotes OR = 1.2, 0.4-4.2) or when considered by racial groups or when limited to younger women (<54 years:carriers OR = 1.4, 0.7-2.6 or homozygotes OR = 3.1, 0.7-14.3).
Keywords
Epidemiology; Statistical-analysis; Cancer; Breast-cancer; Humans; Women; Genetic-factors; Age-factors; Age-groups; Racial-factors; Demographic-characteristics
Contact
Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
CODEN
AJHGAG
Publication Date
20001001
Document Type
Abstract
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
0002-9297
NIOSH Division
HELD
Source Name
American Journal of Human Genetics
State
WV; NY
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