Pulmonary effects of single-walled carbon nanotubes: inflammatory response, oxidative stress/signaling, and recognition by macrophages.
Kagan VE; Rao KMK; Kisin ER; Young SH; Meighan T; Murray AR; Tyurina YY; Castranova V; Shvedova AA
Nanotechnology - toxicological issues and environmental safety (NATO science for peace and security series / NATO science for peace and security series C: environmental security). Simeonova PP, Opopol N, Luster MI. eds. Dordrecht, The Netherlands: Springer, 2007 May; :65-75
Nanosized materiaols and nano-scaled processes are believed to be beneficial for many industries as well as for medicine. However, irrational unjustified use of nanomaterials may also pose risks to human health and the environment, particularly single-walled carbon nanotubes, such as their decytotoxid effects, their ability to cause an inflammatory response, and induction of oxidative stress. Further, recognigion and engulfment of nanotubes in tissue and circulation are discussed. Possible involvement of lung fibroblast pulmonary responses to nanotubes are considered.
Aerosols; Aerosol-particles; Airborne-particles; Airborne-fibers; Toxicology; Nanotechnology;
Author Keywords: occupational exposure; free radicals; lung fibrosis; neutrophils; transition
Pathology/Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
Simeonova PP; Opopol N; Luster MI
Nanotechnology - toxicological issues and environmental safety (NATO science for peace and security series / NATO science for peace and security series C: environmental security)
University of Pittsburgh at Pittsburgh