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The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone in the Third National Health and Nutrition Examination Survey.

Authors
Krieg EF Jr.
Source
Environ Res 2007 Jul; 104(3):374-382
NIOSHTIC No.
20032324
Abstract
The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone were assessed in a nationally representative sample of women, 35-60 years old, from the third National Health and Nutrition Examination Survey. The blood lead levels of the women ranged from 0.7 to 31:1 mg/dl. The estimated geometric mean was 2:2 mg/dl, and the estimated arithmetic mean was 2:8 mg/dl. As the blood lead level increased across women, the concentration of serum follicle stimulating hormone increased in post-menopausal women, women who had both ovaries removed, and pre-menopausal women. The concentration of follicle stimulating hormone decreased in pre-menopausal women who were taking birth control pills. The concentration of luteinizing hormone increased as blood lead level increased in post-menopausal women and women who had both ovaries removed. The lowest concentrations of blood lead at which a relationship was detected were 1:7 mg/dl for follicle stimulating hormone and 2:8 mg/dl for luteinizing hormone. The increase in follicle stimulating hormone and luteinizing hormone in women with no ovaries indicates that lead may act at a non-ovarian site in the female reproductive system, along with a possible effect on the ovaries.
Keywords
Analytical-processes; Hormones; Hormone-activity; Women; Age-factors; Lead-absorption; Blood-analysis; Blood-serum; Reproduction; Reproductive-effects; Reproductive-system
Contact
EF Krieg Jr, National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, MS C-22, Cincinnati, OH 45226
CODEN
ENVRAL
Publication Date
20070701
Document Type
Journal Article
Email Address
erk3@cdc.gov
Fiscal Year
2007
Issue of Publication
3
ISSN
0013-9351
NIOSH Division
DART
Source Name
Environmental Research
State
OH; CA
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division