Incomplete removal of the pesticide captan from skin by standard handwash exposure assessment procedures.
Fenske-RA; Schulter-C; Lu-C; Allen-EH
Bull Environ Contam Toxicol 1998 Aug; 61(2):194-201
The dermal route of exposure is often the primary route of occupational exposure to pesticides, and several investigators have reported that over 60% of the total absorbed dose was contributed by the dermal route (Durham et al. 1972; Fenske and Elkner 1990). Although handwashing procedures to assess occupational dermal exposure have been standard practice for several decades (Durham and Wolfe 1962), the validity of these results are not typically addressed. As a significant quantity of pesticide may remain sorbed to the skin on the hands, handwashing procedures probably underestimate exposure. Moreover, for those pesticides that most sorb to skin, handwashing exposure assessment procedures result in the most significant underestimates of the physiologically relevant dose. The purpose of this study was to determine the removal efficiency of the pesticide captan from participants' hands. Removal efficiency is defined here as the ratio of captan removed from the hand by handwashing to the total captan originally on the hand. Captan (3a,4,7,7a-Tetrahydro-2-(trichloromethyl)thio)IH-isoindole-1,3(2H)-dione), CAS registry number 133-06-2, is a foliar fungicide used widely, and increasingly, in agricultural production, as well as in consumer pesticide products (Hayes and Laws 1991). It is classified as a probable human carcinogen (Group B2) by the U.S. Environmental Protection Agency, and it has been reported to cause contact dermatitis (Hayes 'and Laws 1991). This laboratory study demonstrates that removal of captan from hands by handwashing is incomplete, with only 68% of captan recovered from hands when handwashing was conducted one hour after hand contact with the pesticide.
Pesticides; Exposure-assessment; Exposure-levels; Occupational-dermatitis; Occupational-exposure; Occupational-hazards; Dermatology; Hand-protection; Sanitation; Skin; Skin-absorption; Skin-exposure; Decontamination; Agricultural-chemicals; Agricultural-workers; Fungal-diseases; Fungal-infections; Fungicides
Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle 98195
Neurotoxic Disorders; Neurotoxic-effects
Bulletin of Environmental Contamination and Toxicology
University of Washington, Seattle, Washington