In October 2000, the United States Congress passed the Energy Employees Occupational Illness Compensation Program Act (EEOICP A), PL 106-398, 3623. On 7 December 2000, the President issued E.O. 13179 assigning roles under EEOICP A to the U.S. Department of Health and Human Services (HHS), the U.S. Department of Labor (DOL), and the U.S. Department of Energy (DOE). The role assigned to HHS included the promulgation of two regulations central to the adjudication of cancer-related claims and to consider procedures for the evaluation of petitions for adding classes of workers to the Special Exposure Cohort. The first of these rules, 42 CPR Part 81, establishes guidelines to determine whether an individual with cancer shall be found "at least as likely as not" to have sustained that cancer from exposure to ionizing radiation in the performance of duty for nuclear weapons production programs of the U.S. Department of Energy (DOE) and its predecessor agencies. These "probability of causation" guidelines will be used for the adjudication of cancer claims by the U.S. Department of Labor (DOL), which has lead responsibility to administer this federal compensation program. The second of these rules, 42 CPR Part 82, establishes the methods by which HHS will estimate the doses of radiation incurred by individual employees of nuclear weapons production programs. This presentation discusses 1) the approach NIOSH has taken to implement its roles and responsibilities under the EEOICP A; 2) NIOSH's interaction with the DOL and DOE; and 3) the overall status of the program.