Risk of laryngeal cancer by occupational chemical exposure in Turkey.
Elci-OC; Akpinar-Elci-M; Blair-A; Dosemeci-M
J Occup Environ Med 2003 Oct; 45(10):1100-1106
Laryngeal cancer is the second most common cancer among men in Turkey. In this hospital based case-control study, we evaluated laryngeal cancer risks from occupational chemical exposures. We analyzed 940 laryngeal cancer cases and 1519 controls. Occupational history, tobacco, and alcohol use and demographic information were obtained by a questionnaire. The job and industries were classified by special seven-digit codes. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) based on a developed exposure matrix for chemicals, including diesel exhaust, gasoline exhaust, polycyclic aromatic hydrocarbons (PAHs), formaldehyde, and solvents. An excess of laryngeal cancer occurred with diesel exhaust (OR = 1.5, 95% CI = 1.3-1.9), gasoline exhaust (OR = 1.6, 95% CI = 1.3-2.0), and PAHs (OR = 1.3, 95% CI = 1.1-1.6). There was a dose-response relationship for these substances with supraglottic cancers (P < 0.000). The PAH association only occurred among those who also had exposure to diesel exhaust.
Larynx-cancer; Occupational-exposure; Risk-analysis; Risk-factors; Respiratory-system-disorders; Cancer; Men; Demographic-characteristics; Smoking; Alcoholic-beverages; Questionnaires; Diesel-exhausts; Polycyclic-aromatic-hydrocarbons; Formaldehydes; Solvents; Natural-gas; Dose-response; Throat; Throat-disorders; Fuels; Exhaust-gases
National Institute for Occupational Safety and Health, Division of Respiratory Diseases Studies, Field Studies Branch, MS2800, 1095 Willowdale Road, Morgantown, WV 26505
Journal of Occupational and Environmental Medicine