Assessing occupational exposures in studies of major birth defects.
Lawson-CC; Waters-MA; Stewart-PA
Am J Epidemiol 2007 Jun; 165(11)(Suppl):S97
Over half of U.S. children are born to working women, and 65% of employed men and women are of reproductive age. Most chemicals used in the workplace, however, have not been evaluated for reproductive toxicity. Studying workers exposed to these chemicals is important for establishing safe limits to protect workers and their offspring. Because workers are often among the most highly exposed, such research can also lead to recommendations for lower exposures in the general public. Characteristics of occupational exposure assessment in birth defects research include a relatively short time between exposure and effect and specific critical exposure windows during development. The combination of rare outcomes and low exposures inherent in population-based studies results in the need for the most accurate available methods for retrospective exposure assessment in order to detect significant risk factors. Issues in occupational exposure assessment will be discussed, and improvements in methods will be highlighted.
Health-hazards; Environmental-hazards; Environmental-factors; Environmental-exposure; Women; Reproductive-hazards; Reproductive-effects; Reproductive-system-disorders; Occupational-exposure; Work-environment; Worker-health; Public-health
American Journal of Epidemiology. Abstracts of the 40th Annual Meeting Society for Epidemiologic Research Boston, Massachusetts, June 19-22, 2007