Permeation of a malathion formulation through nitrile gloves.
Lin-YW; Que Hee-SS
Appl Occup Environ Hyg 1998 May; 13(5):286-298
Factors determining the permeation of a malathion formulation (Prent) and a reconstituted mixture of 12 components (Recon), 11 being alkybenzenes, were investigated for a lined, unsupported nitrile glove in an American Society for Testing and Materials-type permeation cell with liquid collection and gas chromatography/mass spectrometry analysis. Only the factors for both Prent and Recon that did not differ significantly at p = 0.001 were then used in a virial-type linear regression multivariate model. The logarithm of the steady-state permeation rate Ps correlated best with the logarithm of the composition of the challenge solutions (weight percentage, %). The liquid molar volume (MV), the logarithm of the octanol-water partition coefficient (log Kow), dipole moment (DM), and the Snyder elution strength (E°) also correlated best in that descending order using the logarithm of the weight percentage as the first term in a linear two-term equation for Ps. After accounting for both % and MV as logarithms, log Kow, DM, and log E° still were correlated significantly to Ps in that descending order. The final equation of best fit involved an initial term for composition (log [%]), a second term related to liquid molecular size (log MV), and a hydrophobicity partitioning term (log Kow). Similar correlations were also found for log(Ps/t1) and log[VR(ts1)], where t1 was the lag time and ts1 was the first observed time in the steady state. This is the first successful model for glove permeation of complex mixtures of more than three components.
Gloves; Chemical-analysis; Nitriles; Analytical-chemistry; Pesticides; Exposure-limits; Skin-tests; Protective-clothing
121-75-5; 121-75-5; 2524-04-1; 108-38-3; 95-47-6; 98-82-8
Applied Occupational and Environmental Hygiene
University of California, School of Public Health, Department of Environmental Health Sciences, Los Angeles, California