Custom made pani fiber to assess dermal partitioning and absorption of biocides.
Yeatts JL; Baynes RE; Riviere JE
Toxicologist 2007 Mar; 96(1):433
A custom-made polyaniline (PANI) coated metal alloy fiber was evaluated for its use in assessing dermal partitioning and absorption of certain biocides. This PANI coating provides a unique functionality compared to three commercially available fibers polyacrylate (PA), polydimethylsiloxane (PDMS), and Carbowax/templated resin. The production of this custom-made fiber is a relatively simple process that can be controlled by utilizing cyclic voltammetry (CV). The CV program for coating the metal alloy fiber consisted of one initial scan from -0.2V to +1.1V followed by several sets of scans from -0.2V to +0.8V with a 15 second equilibration time at -0.2V between scan sets and scan rate of 50 mV/sec. The electrolyte solution was 0.1M aniline in 1.0M sulfuric acid. The bare metal alloy fiber SPME assembly, commercially donated, served as the working electrode. In our experiments, cyclic voltammetry appeared to give more consistent results and control in coating the metal alloy fiber with PANI as opposed to using a constant deposition potential. To assess the PANI fiber, solid-phase microextraction (SPME) was performed by direct immersion into water solutions containing either a single component or a mixture of biocides at 37 degrees C and stir rate of 400 R.P.M. The PANI fiber was desorbed directly in the GC-MS injector port for 5 minutes at 200 degrees C following immersion. This PANI coated fiber exhibited good reproducibility and durability. The RSD's averaged 6 to 9% over a period of three days for the first 46 injections of a single component (5ppm 2-phenylphenol) in water with only three outliers. Time profile experiments revealed that both p-chloro-o-cresol and o-phenylphenol reached equilibrium before 10 minutes while the equilibrium time for o-benzyl-p-chlorophenol was greater than 90 minutes.
Chemical-properties; Chemical-composition; Filter-fabrics; Filter-materials; Filter-membranes; Filtration; Aqueous-solutions
Disease and Injury: Allergic and Irritant Dermatitis
The Toxicologist. Society of Toxicology 46th Annual Meeting and ToxExpo, March 25-29, 2007, Charlotte, North Carolina
North Carolina State University, Raleigh, North Carolina