Carbon nanotube respiratory exposure and risk from systemic effects.
Simeonova PP; Li Z; Erdely A
Toxicologist 2007 Mar; 96(1):137
The most attractive features of nanomaterials including their small size, large surface area, and reactivity might also be the main factors for their toxicity. In this regard, nanoparticles may induce not only higher damage at the penetration site but also can lead to unexpected distant responses as a result of their transclocation and reactivity through the body. Our research efforts are currently directed to evaluate the cardiovascular effects, including vascular inflammation, blood cell coagulation status, atherosclerosis, as well as the related molecular mechanisms associated with respiratory exposure to different forms of carbon nanotubes (CNT) using animal models. We demonstrated that pulmonary exposure to multiple doses of single wall-CNT induces severe lung toxicity and accelerates the progression of atherosclerosis in ApoE-/- mice. This response is accompanied by oxidative modification in the vascular wall and induction of markers which facilitate blood coagulation. The atherogenic effects might be a result of a systemic effects related to the lung toxicity and/or translocation of nanotubes into the systemic circulation. The accumulation of toxicological data on engineered nanomaterials will allow for development of adequate risk assessment and regulations.
Biodynamics; Cardiovascular-function; Blood-vessels; Cardiovascular-function-tests; Cardiovascular-system-disorders; Respiratory-infections; Respiratory-irritants; Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disorders; Nanotechnology
The Toxicologist. Society of Toxicology 46th Annual Meeting and ToxExpo, March 25-29, 2007, Charlotte, North Carolina