Development of a small inhalation system for rodent exposure to fine and ultrafine titanium dioxide aerosols.
Chen B; Frazer D; Stone S; Schwegler-Berry D; Cumpston J; McKinney W; Lindsley B; Frazer A; Donlin M; Vandestouwe K; Castranova V; Nurkiewicz T
Proceedings of the Seventh International Aerosol Conference, September 10-15, 2006, St. Paul, Minnesota. Biswas P, Chen DR, Hering S, eds. Mount Laurel, NJ: American Association for Aerosol Research, 2006 Sep; :858-859
There has been great attention paid to the potential health effects of fine and ultrafine particles in the working environment. It is not only because of the increased application and use of fine/ultrafine powders in industry, but also due to the concern regarding the association between increased risk of morbidity and mortality and particulate air pollution on PM2,5 and PM(10) (Samet et al. 2000). Although the data imply that PM can affect tissues and organs outside the respiratory tract, as evidenced by the occurrence of cardiovascular dysfunction (Goldberg et al. 2000), the biological mechanisms which evoke systematic effects remain to be defined. In this collaborative research between NIOSH and WVU, we try to understand the mechanisms by identifying significant effects of pulmonary PM exposure on the systemic microcirculation (Nurkiewicz et al. 2004). As an initial step in this effort, a small-scale inhalation system was developed to expose rats to fine/ultrafine TiO2 aerosols.
Aerosols; Inhalation-studies; Exposure-chambers; Laboratory-animals; Particulates; Nanotechnology
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
Biswas P; Chen DR; Hering S
Proceedings of the Seventh International Aerosol Conference, September 10-15, 2006, St. Paul, Minnesota