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Effect of cetirizine on early- and late-phase airway responses in a Brown Norway rat model of allergic asthma.
J Allergy Clin Immunol 2007 Jan; 119(1)(Suppl 1):S301
Rationale: The effect of Cetirizine, a selective H1-receptor antagonist, was studied in the Brown Norway rat (BNR) model of trimellitic anhydride (TMA) early and late phase allergic asthma. Methods: Rats were sensitized by 4 hr, weekly applications of 40 mg dry TMA powder on the rats' dorsum for 4 weeks. Two weeks after the final exposure, BNR were challenged with a 10 min, 40 mg/m3 TMA aerosol inhalation exposure and enhanced pause (Penh, an index of airway resistance) was recorded continuously overnight. Cetirizine (15 or 30 mg/kg, i.p.) was given 30 min before or 1 hr after TMA challenge. Results: Both doses of Cetirizine when administered 1 hr after TMA challenge attenuated the late-phase airway response (LAR). Thirty mg/kg Cetirizine administered prior to airway challenge did not inhibit the early-phase airway response (EAR), but again the late-phase airway response was inhibited. Conclusions: The data suggest that the H-1 histamine receptor does not play a major role in the EAR, but is involved in LAR physiological response in the BNR TMA allergic asthma model.
Allergens; Allergic-reactions; Allergies; Laboratory-animals; Animal-studies; Animals; Respiratory-system-disorders; Pulmonary-system-disorders
Abstract; Conference/Symposia Proceedings
Issue of Publication
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
Journal of Allergy and Clinical Immunology
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