Latex allergy has influenced everyday medical practice, healthcare policy decisions and industry modifications, which were necessary to deal with this rapidly growing disease. A recent study of latex-allergic patients clearly demonstrated a decline in latex sensitization. This was partly due to the decline in levels of the allergenic proteins on gloves. However, in some patients, latex allergy disappeared with a conversion to a negative in-vivo- and in-vitro-specific IgE test. This is another area where latex allergy research can enter into an area of the unknown. The natural history of allergic diseases is largely unknown. With the removal of the major source of sensitization, the next decade may witness the continued decline and disappearance of latex allergy. However, it must be stressed that present-day avoidance precautions are still mandatory in all latex allergic patients.