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Airway responses in Brown Norway rats following inhalation sensitization and challenge with trimellitic anhydride.
Zhang-XD; Andrew-ME; Hubbs-AF; Siegel-PD
Toxicol Sci 2006 Dec; 94(2):322-329
Trimellitic anhydride (TMA) is a cause of asthma in man. Dose-dependent TMA-specific IgE, histopathology, and airway responses after sensitization by inhalation were examined in the Brown Norway rat. Rats were exposed to 0.04, 0.4, 4, or 40 mg/m(3) TMA aerosol for 10 min, once a week, over 10 weeks. All lower exposures were, subsequently, rechallenged to 40 mg/m(3) TMA aerosol. All rats received a sham exposure 1 week prior to the first TMA exposure. Following the sham exposure and weekly after each TMA exposure, TMA-specific IgE and both early-phase airway response (EAR) and late-phase airway response (LAR) were measured using enhanced pause (Penh). All rats sensitized by 40 mg/m(3) TMA developed specific IgE, EAR, and LAR to one or more of the challenges to 40 mg/m(3) TMA. TMA of 4 mg/m(3) induced a much lower, but stable, specific IgE response. EAR and LAR were observed only after a 40 mg/m(3) TMA rechallenge in this group, but it was much larger than that observed in the 40 mg/m(3) TMA-sensitized and challenged group. Exposure-dependent histopathological changes noted included eosinophilic granulomatous interstitial pneumonia, perivascular eosinophil infiltrates, bronchial-associated lymphoid tissue hyperplasia, and peribronchiolar plasma cell infiltrates.
Chemical-properties; Resins; Dyes; Dye-industry; Adhesives; Polymers; Printing-inks; Pharmaceuticals; Plasticizers; Agricultural-chemicals; Allergic-reactions; Allergic-dermatitis; Mucous-membranes; Immune-reaction; Laboratory-animals; Animals; Animal-studies; Sensitization
Allergy and Clinical Immunology Branch, M/S L4020 HELD/NIOSH, 1095 Willowdale Road, Morgantown, WV 26505-2888
Issue of Publication
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division