Possible genotoxic risk in coal workers' pneumoconiosis.
Ulker-OC; Ustundag-A; Duydu-Y; Yucesoy-B; Karakaya-A
Toxicol Lett 2006 Sep; 164(Suppl 1):S35
Occupational exposure to coal dust causes coal workers' pneumoconiosis (CWP) which is a chronic inflammatory and fibrotic lung disease. In recent years chronic inflammation is accepted a common important factor in the pathogenesis of neoplasia. The chronic inflammation provides dynamic setting for oxidative stress and formation of free radicals. Interaction of reactive oxygen species (ROS) with DNA augments the likelihood of DNA structural and transcriptional errors. To investigate the genotoxic risk of occupational exposure to coal dust in CWP patients, sister chromatid exchange (SCE) and micronucleus (MN) tests were performed on CWP patient group (n = 23), coal workers group (n = 29) and unexposed control group (n = 29). Both SCE and MN frequencies in CWP patients were found significantly higher than in coal workers and unexposed group. There were no differences between coal workers and unexposed groups' SCE and MN frequencies. While positive correlations between SCE frequency and the exposure duration time or age were found in coal workers, no correlations were found in other two groups. There was no effect of smoking on the frequencies of SCE and MN in all three groups. Based on these results, it can be suggested that development of CWP related to occupational exposure to coal mine dust leads to a significant induction of cytogenetic damage in peripheral lymphocytes of CWP patients.
Genotoxicity; Genotoxic-effects; Risk-factors; Risk-analysis; Coal-workers; Coal-workers-pneumoconiosis; Coal-dust; Occupational-exposure; Dusts; Dust-particles; Dust-exposure; Lung-disease; Occupational-diseases; Diseases; Free-radicals; Free-radical-generation
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease