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Familial risk of lung cancer among nonsmokers and their relatives.

Authors
Schwartz-AG; Yang-P; Swanson-GM
Source
Am J Epidemiol 1996 Sep; 144(6):554-562
NIOSHTIC No.
20031094
Abstract
The role of family history of lung cancer in predicting lung cancer risk among nonsmokers and their relatives was evaluated in a population-based family study conducted in metropolitan Detroit. Lung cancer risk factor data were collected through telephone interviews with 257 nonsmoking lung cancer cases 40-84 years of age diagnosed between 1984 and 1987, their 2,252 relatives, 277 nonsmoking controls, and their 2,408 relatives. Lung cancer in a first-degree relative was associated with a 7.2-fold (95% confidence interval 1.3-39.7) increased risk of lung cancer among nonsmokers in the 40- to 59-year-old age group. This significant increased risk remained after adjustment for the smoking, occupational, and medical history of each family member (relative risk = 6.1, 95% confidence interval 1.1-33.4). Offspring of nonsmoking cases comprised another lung cancer high risk group (relative risk = 7.2, 95% confidence interval 0.5-103). A positive family history did not increase lung cancer risk among nonsmokers 60-84 years of age or their relatives. These findings suggest that susceptibility to lung cancer in families of nonsmoking cases may be evident only in a subset of relatives of early-onset nonsmoking cases.
Keywords
Epidemiology; Risk-factors; Risk-analysis; Cancer; Lung-cancer; Demographic-characteristics; Age-factors; Age-groups; Lung-disease; Diseases; Genetics; Environmental-exposure; Models; Case-studies; Author Keywords: family health; genetics; lung diseases; lung neoplasms; risk
Contact
Dr. Ann G. Schwartz, Department of Human Genetics, Allegheny-Singer Research Institute, 320 East North Avenue, Pittsburgh, PA 15212
CODEN
AJEPAS
Publication Date
19960915
Document Type
Journal Article
Funding Amount
1233788
Funding Type
Grant
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-002067
Issue of Publication
6
ISSN
0002-9262
Source Name
American Journal of Epidemiology
State
PA; MI
Performing Organization
Michigan Cancer Foundation, Detroit, Michigan
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