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Acute vibration induces oxidative stress and changes in transcription in soft tissue of rat tails.

Waugh S; Leonard SS; Miller GR; Krajnak KM
Proceedings of the first American conference on human vibration, June 5-7, 2006, Morgantown, West Virginia. Dong R, Krajnak K, Wirth O, Wu J, eds. Morgantown: WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2006-140, 2006 Jun; :160-161
Repeated exposure to hand-arm vibration through the use of vibrating hand tools can result in the development of the disorder known as hand-arm vibration syndrome (HAVS). One of the hallmark symptoms of HAVS is cold-induced peripheral vasospasms that result in finger blanching. Although the vascular and neural pathology associated with vasospasms has been described, little is known about cellular mechanisms leading to this damage. To understand how vibration may alter vascular and neural physiology and anatomy, rats were exposed to a single bout of tail vibration and the molecular responses of neural and vascular tissues were measured to determine if there are immediate or sustained affects of vibration that may underlie longer term changes in physiology.
Vibration; Vibration-disease; Vibration-control; Vibration-effects; Vibration-exposure; Hand-injuries; Neurovascular-disorders; Hand-tools; Power-tools; Animals; Animal-studies; Laboratory-animals
Publication Date
Document Type
Conference/Symposia Proceedings
Dong R; Krajnak K; Wirth O; Wu J
Fiscal Year
NTIS Accession No.
NTIS Price
NIOSH Division
Priority Area
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Source Name
Proceedings of the first American conference on human vibration, June 5-7, 2006, Morgantown, West Virginia