Vibration exposure reduces nitric oxide concentrations in the ventral artery of the rat tail.
Proceedings of the First American Conference on Human Vibration, June 5-7, 2006, Morgantown, West Virginia. Dong R, Krajnak K, Wirth O, Wu J, eds., Morgantown, WV: National Institute for Occupational Safety and Health, 2006 Jun; :158-159
Vibration transmitted to the upper limb by the chronic use of hand tools can result in cold-induced vasospasms finger blanching and cyanosis, similar to that seen with Raynaud's phenomenon (4). These vasospasms, commonly referred to as vibration white finger (VWF), are in part the result of an increased sensitivity of peripheral arteries to the vasoconstricting effects of norepinephrine. However, alterations in vasodilating factors could also contribute to vasospasms. The goal of these studies was to determine if exposure to a single bout of vibration alters concentrations of the vasodilator, nitric oxide (NO), in a rat tail model of vibration. To determine if vibration exposure alters NO, we exposed animals to a single bout of vibration and measured concentrations of the synthetic enzymes, nitric oxide synthetase (NOS)-1 and NOS-3 in the ventral tail artery. We also directly assessed arterial concentrations of NO using a nitrate/nitrite assay.
Vibration-exposure; Vibration; Power-tools; Ergonomics; Hand-tools; Vibration-disease; Vibration-effects; Neurovascular-disorders; Animal-studies; Animals; Laboratory-animals
Dong-R; Krajnak-K; Wirth-O; Wu-J
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Proceedings of the First American Conference on Human Vibration, June 5-7, 2006