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Vibration exposure reduces nitric oxide concentrations in the ventral artery of the rat tail.

Johnson C; Krajnak KM
Proceedings of the first American conference on human vibration, June 5-7, 2006, Morgantown, West Virginia. Dong R, Krajnak K, Wirth O, Wu J, eds. Morgantown: WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2006-140, 2006 Jun; :158-159
Vibration transmitted to the upper limb by the chronic use of hand tools can result in cold-induced vasospasms finger blanching and cyanosis, similar to that seen with Raynaud's phenomenon (4). These vasospasms, commonly referred to as vibration white finger (VWF), are in part the result of an increased sensitivity of peripheral arteries to the vasoconstricting effects of norepinephrine. However, alterations in vasodilating factors could also contribute to vasospasms. The goal of these studies was to determine if exposure to a single bout of vibration alters concentrations of the vasodilator, nitric oxide (NO), in a rat tail model of vibration. To determine if vibration exposure alters NO, we exposed animals to a single bout of vibration and measured concentrations of the synthetic enzymes, nitric oxide synthetase (NOS)-1 and NOS-3 in the ventral tail artery. We also directly assessed arterial concentrations of NO using a nitrate/nitrite assay.
Vibration-exposure; Vibration; Power-tools; Ergonomics; Hand-tools; Vibration-disease; Vibration-effects; Neurovascular-disorders; Animal-studies; Animals; Laboratory-animals
Publication Date
Document Type
Conference/Symposia Proceedings
Dong R; Krajnak K; Wirth O; Wu J
Fiscal Year
NTIS Accession No.
NTIS Price
NIOSH Division
Priority Area
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Source Name
Proceedings of the first American conference on human vibration, June 5-7, 2006, Morgantown, West Virginia