Cytokine Gene Polymorphisms in Multifactorial Conditions. Vandenbroeck K, ed., Boca Raton, FL: CRC Press, 2006 Jun; :351-362
With the identification of the DNA sequence of the human genome and increasing data on polymorphisms, genetic epidemiology offers a powerful approach to the identification of genetic variants that influence susceptibility to many common diseases. Although the pathogenesis of pulmonary fibrosis remains incompletely understood, identification and understanding the role of genetic risk factors helps provide novel insights into the pathophysiology of the disease and identify molecular regulators of inflammatory and fibrotic processes. The use of new high-throughput genotyping technology, statistical genetic methods and robust association study designs which considers population stratification, sample size, intermediate phenotypes, linkage disequilibrium, and gene-gene/gene environment interactions, will help lead to a better understanding of fibrotic mechanisms in the lung and identification of high-risk groups. This information may also aid in the development of novel therapeutic targets at a molecular level.
Respiratory-system-disorders; Pulmonary-system-disorders; Fibrogenesis; Fibrogenicity; Genes; Genetics; Genotoxicity
Book or book chapter
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
Cytokine Gene Polymorphisms in Multifactorial Conditions