Lead exposure and glioma among rural residents: the Upper Midwest Health Study.
Carreon-T; Ruder-AM; Waters-MA; Butler-MA; Yeager-M; Welch-R; Chanock-S; Schulte-PA
Am J Epidemiol 2006 Jun; 163(11)(Suppl):S251
We evaluated lead exposure, blood lead levels (BLL). and the d-aminolevulinic acid dehydratase (ALAD) G177C polymorphism as risk factors for primary intracranial gliomas in a population-based case-control study in rural residents of four states with high glioma incidence. Glioma cases were identified from hospitals, private physicians and registries. Controls were stratified samples of licensed drivers and Medicare enrollees. Blood was from 454 controls with no self-reported cancer and from 318 cases, all Caucasian non-Latinos (>97% of blood donors). Blood lead was measured by atomic absorption spectrometry. Genotypes were characterized by the TaqMan methodology. Questionnaires elicited retrospective occupational and environmental lead exposures. Non-farm jobs involving the use of solder containing lead or the use of lead in wiping, joining, or sweating lead pipe increased the risk of glioma (odds ratio [OR] = 1.4. 95% confi- dence interval [CI]. 1.1-1.9). Conversely, no association with glioma was observed for farm activities with potential lead exposure such as painting, using wood strippers, using gasoline for cleaning equipment, or using pesticides containing lead arsenate. These results lend some support for the hypothesis that lead is a brain carcinogen. BLL were not associated with increased risk of glioma (OR = 0.9, CI. 0.8-1.0), but BLL reflect recent exposures, and are not good indicators of lead exposure in studies of diseases with long latency such as cancer. Having one or two copies of the rarer ALAD allele C177 was not associated with glioma (OR = 0.9, CI. 0.6-1.4), consistent with other studies.
Lead-compounds; Blood-tests; Blood-analysis; Risk-factors; Case-studies; Occupational-exposure; Environmental-exposure
DSHEFS; DART; EID
Research Tools and Approaches: Cancer Research Methods
American Journal of Epidemiology. Abstracts of the 2nd North American Congress of Epidemiology, June 21-24, 2006, Seattle, Washington
OH; MD; IA; MI; MN; WI