COPD and occupational exposures: a case-control study.
Weinmann-S; Vollmer-WM; Breen-V; Heumann-M; Hnizdo-E; Villnave-J; Doney-B; Graziani-M; McBurnie-MA; Buist-S
Am J Epidemiol 2006 Jun; 163(11)(Suppl):S214
Growing evidence suggests that chronic obstructive pulmonary disease (COPD) is causally associated with certain occupations. The authors conducted a case control study among members of Kaiser Permanente Northwest to evaluate the association of COPD with occupational exposures. Subjects included 388 COPD cases aged 45 and over matched on age group, sex, and cigarette smoking history to 356 controls. Occupation and smoking histories were obtained by telephone interview. Industrial hygienists independently rated each job within an individual's history according to its likelihood of exposure to eight occupational hazard categories thought to cause COPD. Odds ratios (ORs) for the presence of each individual exposure hazard category and for aggregate exposure variables were computed using logistic regression, stratifying on smoking status and adjusting for age, sex, and, for smokers, pack years. Among ever-smokers, occupational exposures most strongly associated with COPD were diesel exhaust (OR = 1.7, 95% CI: 1.1, 2.7) and irritant gases and vapors (OR = 1.7, 95% CI: 2, 2.4). Associations with metal dust and mineral dust were suggested. In the small group of never-smokers (42 cases and 58 controls), a similar pattern was evident. Odds ratios for the overall aggregate exposure measure were 1.5 (95% CI: 1.0, 2.2) for ever-smokers and 1.5 (95% CI: 0.61, 3.7) for never-smokers. These population-based findings add to the literature linking occupational exposures to COPD.
Occupational-exposure; Case-studies; Pulmonary-system-disorders; Occupational-diseases; Diseases; Demographic-characteristics; Age-factors; Age-groups; Sex-factors; Smoking; Cigarette-smoking; Diesel-exhausts; Vapors; Gases; Surveillance
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease; Construction
American Journal of Epidemiology. Abstracts of the 2nd North American Congress of Epidemiology, June 21-24, 2006, Seattle, Washington