The role of ferrous iron in dust-induced carcinogenesis.
Huang-X; Pezerat-H; Elias-Z; Costa-M
Toxicologist 1995 Mar; 15(1):312-313
Increasing evidence demonstrates that an excess of lung cancer and stomach cancer has been observed in iron ore and steel factories workers. It has been shown that the incidence of cancer is related to the exposure to mineral dusts. Moreover, many studies have shown that the iron content of the asbestos fibers has an important role in the generation of reactive oxygen species (ROS) and in the induction of mesothelioma. In the present study, we found that FeS04 in aqueous solution and aged pyrite (FeS2) which contained a coating of FeS04 produced ROS following interaction with 02, as detected by the spin trapping agent DMPO with ESR. We have also found that FeS04 in solution is toxic to Syrian hamster embryo (SHE) cells, but not transforming. Aged pyrite with 8 coating of FeS04 was not very toxic, but transformed SHE cells. These results suggest that very little Fe2+ ions can get into cells and ROS resulting from interaction of water soluble FeS04 and O2 may damage cell membrane which causes cell toxicity. The aged pyrite which was phagocytized and subsequently released Fe2+ in SHE cells induced transformation of cells. Therefore, the role of reactive Fe2+ in airborn dusts is a parameter which is worth considering in order to predict which dusts will lead to a higher incidence of cancer. The mechanism of Fe2+-containing dust-induced cell transformation is being studied.
Lung-cancer; Lung-disease; Lung-disorders; Lung-irritants; Stomach-disorders; Stomach-cancer; Cancer; Cancer-rates; Metal-industry-workers; Metal-poisoning; Metal-workers; Iron-workers; Iron-working-industry; Steel-industry; Steelworkers; Dust-particles; Dust-exposure; Dust-inhalation; Dust-analysis
The Toxicologist. Society of Toxicology 34th Annual Meeting, March 5-9,1995, Baltimore, Maryland