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Effects of solvents on recovery of selected pesticides from an in vitro porcine skin model.
Campbell-JL; Eiteman-MA; Williams-PL; Boeniger-M; Smith-MA
Toxicologist 1996 Mar; 30(1)(Part 2):52
Skin exposure to pesticides are a health concern for agricultural workers. Historically, worker's hand exposure has been evaluated by washing or wiping the hands with a solvent-moistened towelette and determining recoveries. Recent evidence indicates that solvents can facilitate percutaneous absorption by: 1) acting as carriers of pesticides, 2) decreasing the skin barrier properties, and 3) by irritating the skin. The purpose of this study was to evaluate the efficiency of 1-propanol, polyethylene glycol, soap and water, or D-TAM in removing selected pesticides from skin. Alachlor (Al) and glyphosate (Gl) were selected as test pesticides based on their chemical properties. C-labeled pesticide was spiked into formulations (Roundup for GI and Lasso for Al) and applied to isolated porcine skin (2.5 ug/cm2). After a 90 min exposure, the skin was wiped with a solvent-moistened gauze. The gauze was analyzed for radioactivity. Based on recovery of radiolabled pesticide, soap and water was the most efficient at removing Gl in the porcine model system. Recovery from the wipe was 48 +/- 6%. Recoveries for other wipe solvents were <40%. For Al, 1-propanol, PEG, and soap and water gave recoveries between 42 and 45% in this model system. Two other pesticides, trifluralin and methyl parathion, have been selected for further investigations based on solubility and other chemical properties.
Solvents; Pesticides; Pesticides-and-agricultural-chemicals; In-vitro-studies; In-vitro-study; Models; Skin-exposure; Skin-tests; Agriculture; Agricultural-workers; Agricultural-industry; Agricultural-chemicals; Occupational-exposure; Skin-irritants; Exposure-levels; Exposure-assessment
Issue of Publication
The Toxicologist. Society of Toxicology 35th Annual Meeting, March 10-14,1996, Anaheim, California