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Aerosol inhalation lessons and applications based on the ICRP 66 lung deposition model.
49th Annual Meeting of the Health Physics Society, July 11-15, 2004, Washington D.C. McLean, VA: Health Physics Society, 2004 Jul; :52
This PEP course illustrates practical aerosol science lessons and applications of the International Commission on Radiological Protection Publication 66 Human Respiratory Tract Model (HRTM) (ICRP 1994). Models including the LUDEP Personal Computer Program for Calculating Internal Doses using the ICRP Publication 66 Respiratory Tract Model will be used to illustrate the importance of knowing aerosol properties such as particle size and human subject properties such as breathing rate. Approaches for obtaining needed aerosols properties will be illustrated. Industrial hygiene examples will include respiratory tract deposition of beryllium and anthrax. The new HTRM is a general update of the Lung Model in ICRP Publication 30 (ICRP 1979) for adult workers, and is significantly broader in scope. It applies explicitly to workers and all members of the public, for (1) inhalation of particles, gases and vapors; (2) evaluation of dose (or material retention) in sensitive regions of the respiratory tract, for a given intake or exposure, and; (3) interpretation of bioassay data. The HTRM provides a physiologically realistic framework for modeling respiratory tract retention and excretion characteristics, and the resulting respiratory tract and systemic organ doses. It enables knowledge of the aerosol characteristics, dissolution and absorption behavior of specific materials to be used in a realistic manner, and calculates meaningful doses in relation to the morphological, physiological, and radiobiological characteristics of the various tissues of the respiratory tract.
Aerosols; Aerosol-particles; Inhalants; Inhalation-studies; Models; Lung; Breathing; Industrial-hygiene; Respiratory-rate; Respiratory-system-disorders; Workers; Worker-health; Occupational-health; Occupational-exposure; Exposure-assessment
Abstract; Conference/Symposia Proceedings
49th Annual Meeting of the Health Physics Society, July 11-15, 2004, Washington D.C.
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division