Microsomal epoxide hydrolase gene polymorphisms, endotoxin exposure and lung function decline in textile workers.
Christiani-DC; Hang-JQ; Zhou-W; Wang-XR; Zhang-HQ; Sun-BX; Dai-HL; Su-L
Proc Am Thorac Soc 2005 May; 2(Abstracts):A918
Occupational exposed to endotoxin in organic dust may induce acute and chronic lung function decline. Microsomal epoxide hydrolase (mEH) detoxifies reactive oxygen species generated by endotoxin exposure. Polymorphisms of this gene are associated with altered enzyme activity. We investigated the associations between mEH polymorphisms, endotoxin exposure, and lung function decline in a prospective study of 265 workers exposed to endotoxin and 234 controls. The population was divided into rapid and slow decline groups by the annual decline rate of lung function (FEV1 greater or less than 40 ml) during the 20 year follow up. mEH Tyr113His and His139Arg polymorphisms were genotyped by the 5' nuclease assay (TaqMan). Results were analyzed using multiple logistic regression models, adjusting for relative covariates. A stronger association between endotoxin exposure and rapid lung function decline was found among mEH genotypes associated with lower enzyme activity, with an adjusted odds ratios (AORs) of 1.74 (95% confidence interval, 0.71-4.28), 2.07 (0.99-4.33), and 4.79 (1.31-17.60) for Tyr/Tyr, Tyr/His, and His/His genotype groups, respectively, for the Tyr113His polymorphism; and 2.31 (0.72-7.41) and 2.25 (1.27-3.99) for Arg/Arg + His/Arg and His/His genotypes, respectively, for the His139Arg polymorphism. We conclude that in mEH polymorphisms may modify the association between occupational endotoxin exposure and lung function decline.
Endotoxins; Lung-function; Workers; Worker-health; Occupational-exposure; Textiles; Textile-mills; Textile-workers; Organic-dusts; Genes; Enzymes; Models; Lung-disorders; Pulmonary-system-disorders
Abstract; Conference/Symposia Proceedings
Issue of Publication
Proceedings of the American Thoracic Society. 2005 ATS International Conference, May 20-25, 2005, San Diego, California