Monitoring cholinesterases: an example of translational research.
Wilson-BW; Nihart-V; Henderson-JD; Ramirez-A; Arrieta-DE
Toxicologist 2006 Mar; 90(1):159
Recently, the phrase "translational research" has been used to refer to projects that carry fundamental studies from the bench to clinical application. One of these arenas is the dangers posed by the modern age of pesticides and chemical warfare that require rapid, reliable, one size fits all biomonitoring. Such biomarkers include blood cholinesterases (ChEs) used to detect exposures to organophosphates and carbamates. California and Washington currently monitor pesticide and the DOD monitors chemical warfare agent handlers. Elsewhere, ChEs are determined if exposures are suspected. Surprisingly, there are few efforts to form a common database to assist public health agencies to make rapid decisions in emergency situations. This presentation reviews a decade of research translating the results of colorimeteric and pH ChE bench assays into a convertible format and to provide rapidly accessible blood ChE data to decide if dangerous exposures have occurred. Problems encountered in standardizing the assays, converting from one assay to another and the reliability of clinical laboratories are discussed and recommendations made for establishing a national data base.
Pesticides; Pesticides-and-agricultural-chemicals; Chemical-warfare-agents; Monitoring-systems; Biomarkers; Exposure-assessment
The Toxicologist. Society of Toxicology 45th Annual Meeting and ToxExpo, March 5-9, 2006, San Diego, California