NIOSHTIC-2 Publications Search

Cognitive effects of chronic exposure to lead and solvents.

Authors
Fiedler-N; Weisel-C; Lynch-R; Kelly-McNeil-K; Wedeen-R; Jones-K; Udasin-I; Ohman-Strickland-P; Gochfeld-M
Source
Am J Ind Med 2003 Jun; 44(4):413-423
NIOSHTIC No.
20029171
Abstract
Background Occupational exposure to lead and solvents has declined steadily over the past 20 years, however, construction workers continue to be exposed to these neurotoxicants. The purpose of this study was to investigate the cognitive effects of chronic occupational exposure to lead and solvents. Method Based on K-XRFof tibial bone lead and occupational history of solvent exposure, subjects were classified into four exposure groups: lead (N¼40), solvent (N¼39), lead/ solvent (N¼45), and control (N¼33). All subjects completed tests to assess concentration, motor skills, memory, and mood. Results Relative to controls, the lead, solvent, and lead/solvent groups performed significantly more poorly on a test of verbal memory, while the lead and lead/solvent groups were slower than the solvent and control groups on a task of processing speed. Bone lead was a significant predictor of information processing speed and latency of response while solvent exposure was a significant predictor of verbal learning and memory. Conclusions Bone lead was associated with slower speed of processing while exposure to lead and/or solvents reduced efficiency of verbal learning.
Keywords
Lead-compounds; Lead-dust; Lead-fumes; Solvents; Occupational-exposure; Neurotoxic-effects; Neurotoxins; Neurotoxicity; Neurotoxicology; Chemical-indicators; Chemical-properties; Mental-processes; Physiological-response; Psychological-reactions; Psychological-responses; Construction; Construction-workers; Motion-studies; Neuromotor-function; Neuromotor-disorders; Neuromotor-system-disorders; Neuromuscular-function; Neuromuscular-system; Neuromuscular-system-disorders
Contact
Nancy Fiedler, UMDNJ-RWJ Medical School, 170 Frelinghuysen Road, Room 210, Piscataway, NJ 08854
CODEN
AJIMD8
Publication Date
20030601
Document Type
Journal Article
Email Address
nfiedler@eohsi.rutgers.edu
Funding Type
Grant
Fiscal Year
2003
Identifying No.
Grant-Number-R01-OH-003691
Issue of Publication
4
ISSN
0271-3586
Source Name
American Journal of Industrial Medicine
State
NJ
Performing Organization
University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School, Environmental and Occupational Health Sciences Institute
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division