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Median nerve trauma in a rat model of work-related musculoskeletal disorder.
Clark BD; Barr AE; Safadi FF; Beitman L; Al-Shatti T; Amin M; Gaughan JP; Barbe MF
J Neurotrauma 2003 Jul; 20(7):681-695
Anatomical and physiological changes were evaluated in the median nerves of rats trained to perform repetitive reaching. Motor degradation was evident after 4 weeks. ED1-immunoreactive macrophages were seen in the transcarpal region of the median nerve of both forelimbs by 5-6 weeks. Fibrosis, characterized by increased immunoexpression of collagen type I by 8 weeks and connective tissue growth factor by 12 weeks, was evident. The conduction velocity (NCV) within the carpal tunnel showed a modest but significant decline after 9-12 weeks. The lowest NCV values were found in animals that refused to participate in the task for the full time available. Thus, both anatomical and physiological signs of progressive tissue damage were present in this model. These results, together with other recent findings indicate that work-related carpal tunnel syndrome develops through mechanisms that include injury, inflammation, fibrosis and subsequent nerve compression.
Nerve-damage; Nerves; Laboratory-animals; Animals; Animal-studies; Models; Musculoskeletal-system-disorders; Physiological-effects; Fibrosis; Nerve-tissue; Tissue-disorders; Carpal-tunnel-syndrome; Injuries; Occupational-health
Issue of Publication
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Journal of Neurotrauma
Page last reviewed: June 12, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division