NIOSHTIC-2 Publications Search
The use of distortion product otoacoustic emissions in the estimation of hearing and sensory cell loss in noise-damaged cochleas.
Davis-B; Qiu-W; Hamernik-RP
Hear Res 2004 Jan; 187(1-2):12-24
Distortion product otoacoustic emissions (DPOAE), permanent threshold shifts (PTS) and outer hair cell (OHC) losses were analyzed in a population of 187 noise-exposed chinchillas to determine the predictive accuracy (sensitivity and specificity) of the DPOAE for PTS and OHC loss. Auditory evoked potentials (AEP) recorded from the inferior colliculus of the brainstem were used to estimate hearing thresholds and surface preparation histology was used to determine sensory cell loss. The overlapping cumulative distributions and high variability in emission responses for both PTS and OHC loss made it difficult to predict AEP threshold and OHC loss from DPOAE level measurements alone. Using a strict criterion (i.e. emissions better than the 5th percentile of the preexposure DPOAE level, and PTS< or = 5 dB or OHC loss< or = 5%), it was found that the postexposure DPOAE level could be used with reasonable confidence to determine if the status of peripheral auditory system was either normal (i.e. PTS< or = 5 dB) or abnormal (PTS>30 dB or OHC loss>40%). However, the high variability of individual DPOAE responses resulted in a broad region of 'uncertainty' (i.e. 5
or = 50%) or PTS (> or = 35 dB) in noise-exposed chinchillas. Based on an exponential regression analysis of individual subjects, correlations were higher for PTS/DPOAE than for OHC loss/DPOA.
Noise-exposure; Animals; Animal-studies; Threshold-limit-values; Hearing-impairment; Hearing-conservation; Sensitivity-testing; Auditory-system; Hearing-threshold; Laboratory-animals
Auditory Research Laboratory, Plattsburgh State University of New York, 107 Beaumont Hall, 101 Broad St., Plattsburgh, NY, 12901
Issue of Publication
Disease and Injury: Hearing Loss
Plattsburgh State University, New York
Page last reviewed: March 11, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division