Diesel exhaust dispersion in a phospholipid lung surfactant for retention of nano-particulate structure in short-term bioassays.
Shi-XC; Harrison-JC; Gu-ZW; Keane-MJ; Ong-T; Murray-DK; Wallace-WE
Proceedings of the 11th Diesel Engine Emission Reduction (DEER) Conference, August 21-25, 2005, Chicago, Illinois. Washington, DC: Department of Energy, 2005 Aug; :1-38
This is a review of our findings that diesel exhaust particulate matter (DPM) can express genotoxic activities in bacterial or mammalian cells when the DPM is dispersed into a major component, phospholipid, of the surfactant that lines the surface of the deep lung airways and air sacs. Some results are presented from the published literature of National Institute for Occupational Safety and Health (NIOSH) research; and some current research is discussed. The method and findings suggest a way to perform short-term in vitro or in vivo toxicity tests which model a potentially critical step in respirable particle exposure: the adsorption of lung surfactant onto particle surfaces and the subsequent effects on biological availability of particle-borne toxicants under conditions of deposition in the lung.
Diesel-exhausts; Bioassays; Particulates; Genotoxic-effects; Toxic-effects; In-vivo-studies; In-vitro-studies; Lung; Lung-disorders; Pulmonary-system-disorders; Respiratory-system-disorders; Nanotechnology
Proceedings of the 11th Diesel Engine Emission Reduction (DEER) Conference, August 21-25, 2005, Chicago, Illinois.