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Tumor necrosis factor-alpha.
Encyclopedic Reference of Immunotoxicology. Vohr HW, ed., New York: Springer-Verlag, 2005 Jun; :674-677
Tumor necrosis factor-a (TNF-a) is a pleiotropic proinflammatory cytokine that mediates key roles in homeostasis, cell growth and proliferation, tissue damage, repair and chronic diseases. TNF-a production is induced by a plethora of stimuli including bacterial products, oxidative stress, other cytokines, and general tissue damage. As such, this cytokine has a central role in orchestrating many injury and disease states including immunotoxicity.
Cell-growth; Tissue-disorders; Diseases; Chronic-degenerative-diseases; Bacteria; Bactericides; Immunotoxins
Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
Book or book chapter
Encyclopedic Reference of Immunotoxicology
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division