Tumor necrosis factor-alpha.
Encyclopedic Reference of Immunotoxicology. Vohr HW, ed., New York: Springer-Verlag, 2005 Jun; :674-677
Tumor necrosis factor-a (TNF-a) is a pleiotropic proinflammatory cytokine that mediates key roles in homeostasis, cell growth and proliferation, tissue damage, repair and chronic diseases. TNF-a production is induced by a plethora of stimuli including bacterial products, oxidative stress, other cytokines, and general tissue damage. As such, this cytokine has a central role in orchestrating many injury and disease states including immunotoxicity.
Cell-growth; Tissue-disorders; Diseases; Chronic-degenerative-diseases; Bacteria; Bactericides; Immunotoxins
Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
Book or book chapter
Encyclopedic Reference of Immunotoxicology