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Systemic inflammatory mediators contribute to widespread effects in work-related musculoskeletal disorders.
Barr AE; Barbe MF; Clark BD
Exerc Sport Sci Rev 2004 Oct; 32(4):135-142
Recent studies in a rat model have indicated that the pathophysiological mechanisms underlying development of work-related musculoskeletal disorders (WMSDs) include widespread inflammation and subsequent fibrosis at high levels of repetition and force. A systemic inflammatory component may affect tissues not directly involved in task performance, thereby contributing to widespread and puzzling symptoms that are often characteristic of patients with WMSDs.
Animal-studies; Laboratory-animals; Muscular-disorders; Musculoskeletal-system-disorders; Muscle-tissue; Muscle-function; Repetitive-work; Ergonomics; Cumulative-trauma; Cumulative-trauma-disorders
Department of Work Environment, University of Massachusetts Lowell, Lowell, Massachusetts 01854
Issue of Publication
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Exercise and Sport Sciences Reviews
Page last reviewed: May 15, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division