Systemic inflammatory mediators contribute to widespread effects in work-related musculoskeletal disorders.
Barr-AE; Barbe-MF; Clark-BD
Exerc Sport Sci Rev 2004 Oct; 32(4):135-142
Recent studies in a rat model have indicated that the pathophysiological mechanisms underlying development of work-related musculoskeletal disorders (WMSDs) include widespread inflammation and subsequent fibrosis at high levels of repetition and force. A systemic inflammatory component may affect tissues not directly involved in task performance, thereby contributing to widespread and puzzling symptoms that are often characteristic of patients with WMSDs.
Animal-studies; Laboratory-animals; Muscular-disorders; Musculoskeletal-system-disorders; Muscle-tissue; Muscle-function; Repetitive-work; Ergonomics; Cumulative-trauma; Cumulative-trauma-disorders
Department of Work Environment, University of Massachusetts Lowell, Lowell, Massachusetts 01854
Exercise and Sport Sciences Reviews