Conference overview: molecular mechanisms of metal toxicity and carcinogenesis.
Bower JJ; Leonard SS; Shi XL
Mol Cell Biochem 2005 Nov; 279(1-2):3-15
Chronic exposure to many heavy metals and metal-derivatives is associated with an increased risk of cancer, although the mechanisms of tumorigenesis are largely unknown. Approximately 125 scientists attended the 3rd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis and presented the latest research concerning these mechanisms. Major areas of focus included exposure assessment and biomarker identification, roles of ROS and antioxidants in carcinogenesis, mechanisms of metal-induced DNA damage, metal signalling, and the development of animal models for use in metal toxicology studies. Here we highlight some of the research presented, and summarize the conference proceedings.
Metals; Toxins; Toxic-effects; Carcinogens; Carcinogenicity; Carcinogenesis; Exposure-levels; Exposure-assessment; Cancer; Risk-factors; Risk-analysis; Tumorigens; Tumorigenesis; Biomarkers; Animals; Animal-studies; DNA-damage;
Author Keywords: Antioxidants; carcinogenesis; DNA damage; metals; reactive oxygen species
Molecular and Cellular Biochemistry