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Registry-based case-control studies of liver cancer and cancers of the biliary tract nested in a cohort of autoworkers exposed to metalworking fluids.

Bardin JA; Gore RJ; Wegman DH; Kriebel D; Woskie SR; Eisen EA
Scandinavian Journal of Work, Environment & Health 2005 Jun; 31(3):205-211
Results are presented for a registry-based study of hepatobiliary cancer (liver and biliary tract) nested in a cohort of workers from three automobile manufacturing plants with potential exposure to metalworking fluids. Altogether 63 cases of hepatobiliary cancer were identified from the cohort by the Michigan cancer registries. Each case was matched to 10 controls. Odds ratios (OR) were estimated in conditional logistic regression models for lifetime exposure to straight, soluble, and synthetic metalworking fluid and fluid components. Overall, hepatobiliary cancer was not associated with exposure to metalworking fluids. However, when the cases were stratified into liver cancer (N = 39) and biliary tract cancer (N = 24) the risk was nonhomogeneous across the two categories. While liver cancer was not associated with exposure to metalworking fluids, the results suggested a possible excess risk of biliary tract cancer with more than 1.0 mg/m3-years of exposure to straight metalworking fluids [OR 2.7, 95% confidence interval (95% CI) 0.9-7.6], as well as any exposure to chlorinated paraffins (OR 3.9, 95% CI 0.9-17). When exposures to straight metalworking fluids were separated into 10-year exposure periods, the odds ratio increased to 6.24 (95% CI 1.62-24.16) for exposures occurring > 20 years prior to the risk date. There is limited evidence that exposure to straight metalworking fluids is associated with biliary tract cancer. The small numbers of cases of these rare cancers were reflected in the wide confidence intervals, and these findings need to be examined further in other exposed populations.
Case-studies; Liver-cancer; Cancer; Biliary-system-disorders; Metalworking-fluids; Occupational-exposure; Automotive-industry; Automobile-repair-shops; Risk-factors; Risk-analysis; Exposure-levels; Exposure-assessment; Author Keywords: biliary tract cancer; gall bladder cancer; occupational health
Dr Judith A Bardin, Washington State Department of Health, Office of Environmental Health Assessments, PO Box 47846, Olympia, WA 98504-7846, USA
Publication Date
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Journal Article
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Grant-Number-R03-OH-003622; Grant-Number-T42-CCT-122961
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Scandinavian Journal of Work, Environment and Health
Performing Organization
University of Massachusetts Lowell
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division