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Induction of activator protein-1 (AP-1) by asbestos and the inhibitory effect of aspirin.
Sourcebook on asbestos diseases - Volume. 20: asbestos exposure and disease control. Peters GA, Peters PJ, eds. Carlottesville, VA: LEXIS Law Publishing, 1999 Jan; 20:173-196
The following chapter presents what might be an important advance in the treatment and prevention of asbestos-related cancers. Asbestos-induced AP-1 activation, in vitro and in vivo, provides some understanding of the cellular pathology leading to cancer and the mechanisms by which such growth might be inhibited. This chapter indicates that aspirin is just such an inhibitor of the regulating transcription factor AP-1. It suggests the pathways where searches could be made for possible therapeutic agents that might play an important role against asbestos-related malignancies.
Analytical-processes; Analytical-methods; Animal-studies; Animals; Laboratory-animals; Carcinogens; Carcinogenicity; Carcinogenesis; Toxins; Toxic-effects; Cancer; Antioxidants; Exposure-assessment; Statistical-analysis; Respiratory-system-disorders; Pulmonary-system-disorders; Cell-cultures; Cell-damage; Cell-function; Cellular-function; Cellular-reactions; Asbestos-dust; Asbestos-fibers; Asbestos-products
Sourcebook on asbestos diseases - Volume. 20: asbestos exposure and disease control
Page last reviewed: September 2, 2020Content source: National Institute for Occupational Safety and Health Education and Information Division