Induction of activator protein-1 (AP-1) by asbestos and the inhibitory effect of aspirin.
Asbestos Exposure and Disease Control. Soucebook on Asbestos Diseases, Volume 20:. GA Peters and BJ Peters, eds., Carlottesville, VA: LEXIS Law Publishing, 1999 Jan; 20:173-196
The following chapter presents what might be an important advance in the treatment and prevention of asbestos-related cancers. Asbestos-induced AP-1 activation, in vitro and in vivo, provides some understanding of the cellular pathology leading to cancer and the mechanisms by which such growth might be inhibited. This chapter indicates that aspirin is just such an inhibitor of the regulating transcription factor AP-1. It suggests the pathways where searches could be made for possible therapeutic agents that might play an important role against asbestos-related malignancies.
Analytical-processes; Analytical-methods; Animal-studies; Animals; Laboratory-animals; Carcinogens; Carcinogenicity; Carcinogenesis; Toxins; Toxic-effects; Cancer; Antioxidants; Exposure-assessment; Statistical-analysis; Respiratory-system-disorders; Pulmonary-system-disorders; Cell-cultures; Cell-damage; Cell-function; Cellular-function; Cellular-reactions; Asbestos-dust; Asbestos-fibers; Asbestos-products
Book or book chapter
Asbestos Exposure and Disease Control. Soucebook on Asbestos Diseases, Volume 20